gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2 (not β-tubulin), is internalized, and releases MMAE; the payload then binds β-tubulin to disrupt microtubules, causing G2/M arrest and apoptosis. Fc-mediated ADCC may also contribute against HER2+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Vinca domain binding by MMAE payload; inhibits microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06341400
disease_id_num_tar_ref
255
drug_id_num_tar_ref
718