gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR-T cells bind CD19 and, via CD28/CD3zeta signaling, activate T-cell cytotoxicity to kill target cells by perforin/granzyme-mediated lysis and Fas–FasL/cytokine-induced apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
FMC63 scFv epitope on extracellular domain of CD19
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06373081
disease_id_num_tar_ref
2986
drug_id_num_tar_ref
8003