gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19-targeted CAR-T cells bind CD19 on B cells and kill them via immune synapse–mediated cytotoxicity, primarily perforin/granzyme-induced apoptosis (and death receptor pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR-T scFv binds extracellular domain on B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06419166
disease_id_num_tar_ref
2990
drug_id_num_tar_ref
8012