gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
GC012F CAR-T cells bind BCMA on target cells, triggering T-cell activation and immune synapse formation, leading to perforin/granzyme-mediated lysis and apoptotic death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR-T scFv binds extracellular domain on plasmablasts/plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06419166
disease_id_num_tar_ref
2990
drug_id_num_tar_ref
8012