gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific CAR T cells bind CD19 on B cells, triggering CD3ΞΆ signaling with 4-1BB costimulation to activate T cells, which kill targets via perforin/granzyme-mediated cytolysis and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
bispecific CAR target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05800977
disease_id_num_tar_ref
2992
drug_id_num_tar_ref
8016