gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
After CD33-mediated internalization, calicheamicin is released and binds the DNA minor groove, inducing double‑strand breaks that trigger apoptosis and cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Calicheamicin payload binds DNA and induces double-strand breaks
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05955261
disease_id_num_tar_ref
2996
drug_id_num_tar_ref
8027