gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Rituximab binds CD20 on B cells and induces killing via complement-dependent cytotoxicity (membrane attack complex) and Fc-mediated ADCC/ADCP by NK cells and macrophages; it can also directly trigger apoptosis upon CD20 crosslinking.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen; antibody binds conformational epitope on the large extracellular loop
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05527912
disease_id_num_tar_ref
3001
drug_id_num_tar_ref
8046