gene_symbol
GPRC5D
hgnc_id
HGNC:13310
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
BCMA-directed CAR-T cells recognize BCMA, not GPRC5D. They kill BCMA+ cells via CAR-activated T-cell cytotoxicity (perforin/granzyme); GPRC5D+ cells are not targeted unless they co-express BCMA.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
plasma cell-associated GPCR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06429150
disease_id_num_tar_ref
3004
drug_id_num_tar_ref
8057