gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on tumor cells and its Fc engages Fc gamma receptor–bearing immune cells (e.g., NK cells) to mediate ADCC (± complement), killing HER2-positive cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds subdomain IV of the HER2 extracellular domain; inhibits HER2 signaling and receptor shedding; mediates ADCC via Fc.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05918328
disease_id_num_tar_ref
3012
drug_id_num_tar_ref
8082