gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 on target cells and its Fc engages Fcγ receptors on effector cells to trigger ADCC, leading to lysis of HER2+ cells; it also blocks HER2 dimerization/signaling, promoting apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain subdomain II (dimerization arm); blocks HER2 heterodimerization, especially HER2-HER3
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05918328
disease_id_num_tar_ref
3012
drug_id_num_tar_ref
8086