gene_symbol
CD33
hgnc_id
HGNC:1659
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-engineered NK cells recognize CD33 via the activating CAR and directly lyse target cells through NK degranulation (perforin/granzymes); an EMCN iCAR inhibits killing of EMCN+ healthy cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
OR-gated activating CAR target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06325748
disease_id_num_tar_ref
3013
drug_id_num_tar_ref
8087