gene_symbol
FLT3
hgnc_id
HGNC:3765
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR NK cells bind FLT3 via the activating CAR, triggering NK activation and degranulation (perforin/granzymes) to lyse/apoptose FLT3+ cells; an inhibitory CAR for EMCN spares healthy HSCs.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
OR-gated activating CAR target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06325748
disease_id_num_tar_ref
3013
drug_id_num_tar_ref
8087