gene_symbol
EMCN
hgnc_id
HGNC:16041
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Endomucin is bound by an inhibitory CAR (NOT gate) on the engineered NK cells, delivering inhibitory signals that prevent NK activation and cytolytic killing, thereby sparing EMCN-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
NOT-gated inhibitory CAR target to spare healthy HSCs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06325748
disease_id_num_tar_ref
3013
drug_id_num_tar_ref
8087