gene_symbol
IL15RA
hgnc_id
HGNC:5978
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SENTI-202 does not target IL-15Rα for killing; its secreted IL-15 engages IL-15Rα to stimulate immune cell survival/function. Cytotoxicity is directed only at CD33/FLT3+ cells via CAR NK degranulation (perforin/granzymes).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged by calibrated-release IL-15 for NK persistence/function
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06325748
disease_id_num_tar_ref
3013
drug_id_num_tar_ref
8087