gene_symbol
IL2RB
hgnc_id
HGNC:6009
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SENTI-202 CAR-NK cells kill CD33 or FLT3 positive cells via CAR-triggered NK cytolysis (perforin/granzymes). IL-2Rβ (CD122) is not a targeted antigen; released IL-15 signals through CD122 to support immune cells rather than killing CD122+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Component of IL-15 receptor complex engaged by calibrated-release IL-15
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06325748
disease_id_num_tar_ref
3013
drug_id_num_tar_ref
8087