gene_symbol
IL2RG
hgnc_id
HGNC:6010
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD132 (common gamma chain) is part of the IL-15 receptor on NK cells; SENTI-202’s IL-15 stimulates NK cells via CD132 to enhance their killing of CD33/FLT3-positive tumor cells. Cells expressing CD132 are not targeted or directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Component of IL-15 receptor complex engaged by calibrated-release IL-15
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06325748
disease_id_num_tar_ref
3013
drug_id_num_tar_ref
8087