gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
B7-H3–binding CAR activates T cells (via CD3z and IL-7Ralpha signaling), triggering MHC-independent cytolysis of B7-H3+ cells through perforin/granzyme release and death-receptor pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06221553
disease_id_num_tar_ref
266
drug_id_num_tar_ref
744