gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
AZD5492 engages CD3 (and CD8) on T cells to activate them to kill CD20+ B cells via perforin/granzyme; CD3+ T cells are effectors, not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
TCR-CD3 complex component on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06542250
disease_id_num_tar_ref
3019
drug_id_num_tar_ref
8104