gene_symbol
TNFRSF9
hgnc_id
HGNC:11924
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Tisagenlecleucel’s CAR recognizes CD19, not 4-1BB. 4-1BB serves as an internal costimulatory signaling domain in the CAR T cell. Killing is directed at CD19+ cells via T‑cell cytotoxic mechanisms (perforin/granzyme), not at 4-1BB–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular co-stimulatory signaling domain of the CAR; not an external binding target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05809284
disease_id_num_tar_ref
3026
drug_id_num_tar_ref
8121