gene_symbol
CD247
hgnc_id
HGNC:1677
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD3zeta (CD247) is an intracellular signaling domain in T cells used within the CAR; it is not the recognized antigen. Tisagenlecleucel targets CD19 and kills CD19+ cells via CAR-T cytolysis (perforin/granzyme and Fas–FasL) upon CD19 engagement.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular TCR signaling domain of the CAR; not an external binding target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05809284
disease_id_num_tar_ref
3026
drug_id_num_tar_ref
8121