gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CLDN18.2-specific CAR T cells bind CLDN18.2 on target cells, become activated, and kill them via T-cell cytotoxic mechanisms (perforin/granzyme-mediated lysis and cytokine-driven apoptosis), independent of native TCR/MHC.
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
A2 isoform of claudin-18; stomach-specific tight junction protein
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05981235
disease_id_num_tar_ref
3030
drug_id_num_tar_ref
8130