gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD3 is on T cells; the BiTE uses CD3 to activate and redirect T cells to kill BCMA-positive tumor cells via perforin/granzyme-mediated cytotoxicity and cytokine release. CD3+ T cells themselves are not the cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Likely CD3 epsilon (CD3E) subunit targeted, but subunit not specified
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06745687
disease_id_num_tar_ref
3032
drug_id_num_tar_ref
8137