gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2 on target cells, is internalized, and releases MMAE that binds beta-tubulin to disrupt microtubules and induce apoptosis; killing is directed by HER2 recognition, not by beta-tubulin expression.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload target (Vinca site); microtubule inhibitor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06378242
disease_id_num_tar_ref
270
drug_id_num_tar_ref
762