gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Ralpha on eosinophils/basophils; its afucosylated Fc engages CD16a on NK cells to trigger ADCC that kills IL-5Ralpha+ cells. CD16a+ cells act as effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement to induce ADCC by NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06261567
disease_id_num_tar_ref
3052
drug_id_num_tar_ref
8195