gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Fc-engineered IgG1 engages FcγR-bearing effector cells (e.g., NK cells/macrophages) to mediate ADCC/ADCP and deplete CTLA-4–expressing intratumoral regulatory T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05630183
disease_id_num_tar_ref
3053
drug_id_num_tar_ref
8197