gene_symbol
LILRB4
hgnc_id
HGNC:6608
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
LILRB4-targeted CAR-T cells bind LILRB4 on target cells and, upon activation, kill them via perforin/granzyme-mediated cytotoxicity (and apoptotic pathways).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR binds two distinct epitopes on LILRB4
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05548088
disease_id_num_tar_ref
3062
drug_id_num_tar_ref
8216