gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The engager binds CD16 on NK cells and ROR1 on tumor cells, activating NK cells to perform ADCC and kill ROR1-positive tumor cells; CD16-expressing cells (NK cells) are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
NK-cell activating Fc receptor; engages ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06273852
disease_id_num_tar_ref
3087
drug_id_num_tar_ref
8279