gene_symbol
HLA-G
hgnc_id
HGNC:4964
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The bispecific antibody binds HLA-G on target cells and CD3 on T cells, activating and redirecting cytotoxic T cells to kill HLA-G–expressing cells via perforin/granzyme (and Fas/FasL)–mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Tumor-associated antigen on HLA-G–positive tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05769959
disease_id_num_tar_ref
3088
drug_id_num_tar_ref
8280