gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
T-DM1 binds HER2, is internalized, and releases the DM1 payload that inhibits microtubules, causing mitotic arrest and apoptosis; trastuzumab Fc can also mediate ADCC.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab antibody component of ADC binds extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06316531
disease_id_num_tar_ref
3092
drug_id_num_tar_ref
8291