gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
T-DM1 targets HER2, is internalized, and releases DM1 that binds beta-tubulin to inhibit microtubules; beta-tubulin expression alone does not lead to killing without HER2-mediated delivery.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DM1 maytansinoid payload binds tubulin to inhibit microtubule function
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06316531
disease_id_num_tar_ref
3092
drug_id_num_tar_ref
8291