gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The HER2-binding ADC is internalized and releases MMAE, which inhibits tubulin polymerization leading to microtubule disruption, G2/M arrest, and apoptosis; IgG1 Fc can also mediate ADCC against HER2+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05649163
disease_id_num_tar_ref
3099
drug_id_num_tar_ref
8310