gene_symbol
EPCAM
hgnc_id
HGNC:11529
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
M701 bridges EpCAM on tumor cells to CD3 on T cells, activating TCR signaling and inducing cytotoxic T‑cell killing (immune synapse formation, perforin/granzyme release and cytokine‑mediated lysis) of EpCAM‑positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-cell antigen arm (binds EpCAM on epithelial tumor cells)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06432296
disease_id_num_tar_ref
275
drug_id_num_tar_ref
775