gene_symbol
TNF
hgnc_id
HGNC:11892
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infliximab binds transmembrane TNF on cells and elicits Fc-mediated ADCC/CDC, and can trigger reverse-signaling–mediated apoptosis, killing tmTNF-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds both soluble and transmembrane forms; neutralizes trimeric TNF and can mediate CDC/ADCC against mTNF-expressing cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06113913
disease_id_num_tar_ref
3111
drug_id_num_tar_ref
8345