gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Daratumumab binds CD38 on target cells and engages immune effectors via its Fc to mediate ADCC (NK cells), ADCP (macrophages), and CDC (complement), leading to lysis/phagocytic clearance of CD38+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme (ADP-ribosyl cyclase/NADase) on plasma cells and immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05556616
disease_id_num_tar_ref
3119
drug_id_num_tar_ref
8374