gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
ABBV-383 binds CD3ε on T cells and BCMA on myeloma cells to form an immune synapse; activated T cells kill BCMA+ tumor cells (perforin/granzyme), while CD3+ T cells are engaged, not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Low-activating CD3 binder on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05650632
disease_id_num_tar_ref
3123
drug_id_num_tar_ref
8388