gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR-T cells bind CD19 on B-lineage cells and induce T-cell cytotoxicity (perforin/granzyme-mediated apoptosis and/or Fas–FasL), depleting CD19+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR contains 4-1BB (CD137) costimulatory and CD3ζ signaling domains
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06121297
disease_id_num_tar_ref
3124
drug_id_num_tar_ref
8389