gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on target cells and its Fc engages CD16 (FcγRIIIa) on NK cells to trigger ADCC, leading to lysis of HER2-expressing cells; it also inhibits HER2 signaling.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain subdomain IV; blocks HER2 dimerization/signaling and promotes ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06098898
disease_id_num_tar_ref
3126
drug_id_num_tar_ref
8397