gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
GPC3-specific CAR T cells bind GPC3 on target cells, become activated, and kill them via T-cell cytotoxic pathways (perforin/granzyme and Fas–FasL–mediated apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface GPI-anchored heparan sulfate proteoglycan
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06590246
disease_id_num_tar_ref
3131
drug_id_num_tar_ref
8413