gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TSA-T cells recognize the patient-specific neoantigen peptide–HLA-I complex via their TCRs and directly kill target cells by perforin/granzyme-mediated apoptosis (and possibly Fas/FasL).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Multiple individualized TSA epitopes; CD8+ TCR recognition; MHC class I restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06193759
disease_id_num_tar_ref
3137
drug_id_num_tar_ref
8428