gene_symbol
TIGIT
hgnc_id
HGNC:26838
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-TIGIT IgG1 binds TIGIT on target cells and engages Fcγ receptors on NK cells/macrophages, inducing ADCC/ADCP that depletes TIGIT-high cells (e.g., intratumoral Tregs).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Humanized IgG1 with intact Fc enabling ADCC/ADCP; blocks TIGIT interaction with CD155 (PVR) and CD112 (NECTIN2)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05868876
disease_id_num_tar_ref
3138
drug_id_num_tar_ref
8429