gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD38 ADC binds CD38, is internalized, and releases an MMAF/duostatin payload that inhibits tubulin polymerization, causing G2/M arrest and apoptosis of CD38+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen; type II transmembrane ectoenzyme; internalization enables ADC payload delivery
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05308225
disease_id_num_tar_ref
3140
drug_id_num_tar_ref
8432