gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
STI-6129 targets CD38 on cells, is internalized, and releases an MMAF/duostatin payload that binds beta-tubulin to inhibit microtubule polymerization, causing G2/M arrest and apoptosis; beta-tubulin expression alone does not make cells targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Vinca-site binding by MMAF-derived payload; inhibits microtubule polymerization (G2/M arrest)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05308225
disease_id_num_tar_ref
3140
drug_id_num_tar_ref
8432