gene_symbol
CA9
hgnc_id
HGNC:1383
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Girentuximab binds CAIX and delivers 177Lu beta radiation to the bound cell, causing DNA double-strand breaks and radiation-induced cell death (with some cross-fire to nearby cells).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05868174
disease_id_num_tar_ref
3150
drug_id_num_tar_ref
8453