gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Belantamab mafodotin targets BCMA on cells; after internalization, MMAF binds beta-tubulin to inhibit microtubules, causing mitotic arrest and apoptosis (plus Fc-mediated ADCC/ADCP). Beta-tubulin expression alone does not lead to targeting or killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular payload MMAF binds the vinca/auristatin site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05853965
disease_id_num_tar_ref
3165
drug_id_num_tar_ref
8499