gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blocks CD47–SIRPα 'don’t eat me' signaling on CD47+ cells, enabling macrophage FcγR-mediated antibody-dependent phagocytosis (ADCP) and consequent cell death; may also enhance downstream T-cell responses.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks interaction with SIRPα (innate immune checkpoint)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05823480
disease_id_num_tar_ref
23
drug_id_num_tar_ref
58