gene_symbol
PDGFRA
hgnc_id
HGNC:8803
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Imatinib directly inhibits the PDGFRA tyrosine kinase (ATP-competitive), shutting down downstream signaling (e.g., RAS/MAPK, PI3K/AKT), causing growth arrest and apoptosis of PDGFRA-driven cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04808115
disease_id_num_tar_ref
281
drug_id_num_tar_ref
787