gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Mosunetuzumab binds CD3 on T cells to recruit and activate them against CD20+ B cells; the activated T cells kill CD20-expressing targets via perforin/granzyme, not the CD3+ T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor CD3 complex component; bispecific arm that crosslinks to CD20 on B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06926205
disease_id_num_tar_ref
3174
drug_id_num_tar_ref
8516