gene_symbol
STEAP1
hgnc_id
HGNC:11378
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR binding to STEAP1 activates the engineered T cells to kill STEAP1+ cells via perforin/granzyme release and Fas–FasL–mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
extracellular domain on tumor cell surface
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06236139
disease_id_num_tar_ref
3182
drug_id_num_tar_ref
8534