gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Mesothelin-targeted KIR-CAR T cells bind mesothelin on tumor cells, activate, and kill them via perforin/granzyme-mediated cytolysis and death receptor pathways, with cytokine release.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell-surface glycoprotein overexpressed on target tumors
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05568680
disease_id_num_tar_ref
3185
drug_id_num_tar_ref
8540