gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CD38 on target cells and triggers complement-dependent cytotoxicity, Fc-mediated ADCC and phagocytosis, and can induce apoptosis, leading to depletion of CD38+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme (NAD+ glycohydrolase/ADP-ribosyl cyclase); daratumumab binding mediates CDC/ADCC/ADCP and can inhibit CD38 enzymatic activity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06409702
disease_id_num_tar_ref
3186
drug_id_num_tar_ref
8541